Cell Therapy for Parkinson’s Disease

نویسندگان

  • Asuka MORIZANE
  • Jun TAKAHASHI
چکیده

In Parkinson's disease (PD), dopamine neurons in the substantia nigra are degenerated and lost. Cell therapy for PD replaces the lost dopamine neurons by transplanting donor dopamine neural progenitor cells. Cell therapy for PD has been performed in the clinic since the 1980s and uses donor cells from the mesencephalon of aborted embryos. Regenerative medicine for PD using induced pluripotent stem (iPS) cell technology is drawing attention, because it offers a limitless and more advantageous source of donor cells than aborted embryos.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Dopamine-Synthesizing Neurons: An Overview of Their Development and Application for Cell Therapy

Cell-gene therapy is a dynamic constituent of novel medical biotechnology. Neurodegenerative disordersin which damage to or demise of specific brain cell types plays central role, are clear examples of diseasecandidate for cell replacement therapy. Dopaminergic (DAergic) neurons biosynthesize dopamine, a vitalneurotransmitter in the central nervous system. Due to the involveme...

متن کامل

Stem cell-based approach for the treatment of Parkinson\'s disease

  Parkinson’s disease (PD) is the second most common neurodegenerative brain disorder which is around 1.5 times more common in men than in women. Currently, drug medications, surgery, and lifestyle changes are common approaches to PD, while all of them focused on reducing the symptoms. Therefore, regenerative medicine based on stem cell (SC) therapies has raised a promising hope. Various types ...

متن کامل

Four main therapeutic keys for Parkinson’s disease: A mini review

Objective(s): Parkinson’s disease (PD) is characterized by motor and cognitive dysfunctions. The progressive degeneration of dopamine-producing neurons that are present in the substantia nigra pars compacta (SNpc) has been the main focus of study and PD therapies since ages.Materials and Methods: In this manuscript, a systematic revision...

متن کامل

Research Progress of Genetic Modified Bone Marrow Mesenchymal Stem Cell Transplantation for the Therapy of Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disease characterized by progressive degeneration of nigrostriatal dopaminergic (Dopamine, DA) neurons and reduced concentration of striatal dopamine. Traditional therapies for Parkinson’s disease are medication and surgery, while gene therapy and stem-cell therapy have been considered as much more ideal methods recently, such as embryonic stem ce...

متن کامل

CELL REPLACEMENT THERAPY FOR PARKINSON’S DISEASE: The importance of neuronal subtype, cell source and connectivity for functional recovery

........................................................................................... lay summary...................................................................................... svensk populärvetenskapliG sammanfattninG......................... abbreviations..................................................................................... introduCtion................................

متن کامل

The effect of low dose amphetamine in rotenone-induced toxicity in a mice model of Parkinson’s disease

Objective(s): The effects of low dose amphetamine on oxidative stress and rotenone-induced neurotoxicity and liver injury were examined in vivo in a mice model of Parkinson’s disease. Materials and Methods: Male mice were treated with rotenone (1.5 mg/kg, every other day for two weeks, subcutaneously). Mice received either the vehicle or...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 56  شماره 

صفحات  -

تاریخ انتشار 2016